Ng Lai Guan
Professor, Senior Investigator
Professor, Westlake University
Google Scholar：https://shorturl.at/hkDM6
Research Focus
1. Differentiation mechanism and migration characteristics of neutrophils and monocytes
2. Heterogeneity of neutrophils in tumors
3. Functional study of neutrophils in type 2 diabetes
Educational Qualifications
2001 – 2004 | PhD Scholar – The Garvan Institute of Medical Research, University of New South Wales, Faculty of Medicine, Australia | Supervisor: Prof. Fabienne Mackay and Prof. Charles Mackay |
2000 – 2001 | Bachelor of Medical Science Honours (1st Class) – University of New South Wales School of Physiology and Pharmacology, Australia | Supervisor:Prof. Kenneth Williams and Dr Garry Corthals2 of 21 |
1997 – 2000 | Bachelor of Medical Science – University of Sydney, Australia Major in Pathology and Pharmacology | |
Academic Qualifications and Employments
2025-Present | Professor – Westlake University |
2023-2025 | Professor – Shanghai Jiaotong University, China Senior Investigator – Shanghai Immune Therapy Institute, China |
2009-2023 | Principal Investigator – Singapore Immunology Network, Singapore |
2021-2022 | Technology Director – Stronghold Diagnostic Lab (A*STAR), Singapore |
2007-2009 | Research Fellow – The Centenary Institute, University of Sydney, Australia Supervisor: Prof. Wolfgang Weninger |
2006-2007 | Postdoctoral Fellow – The Wistar Institute, Philadelphia, Pennsylvania, USA Supervisor: Prof. Wolfgang Weninger |
2004-2006 | Research Fellow – Institute of Molecular and Cell Biology, Singapore Supervisor: Prof. Kong-Peng Lam |
Awards and Achievements
1. 2018 A*STAR Most Inspiring Mentor Award
2. 2020 Clarivate™ Highly Cited Researchers
3. 2021 Clarivate™ Highly Cited Researchers
4. 2022 Clarivate™ Highly Cited Researchers
5. 2023 Clarivate™ Highly Cited Researchers
6. 2022 National Talent Program Award, China
7. 2022 Shanghai City Talent Program Award, China
8. 2023 Shanghai City High Level Talent Award, China
9. 2024 Clarivate™ Highly Cited Researchers
Academic Position
Member of the Immune Cell Biology Branch, Chinese Society for Cell Biology
Member of the Blood Physiology Committee of the Chinese Physiological Society
Member of the Blood Physiology Committee of the Chinese Physiological Society
Senior editor of Discovery Immunology
Associate editor of Journal of Leukocyte Biology
Editorial board of Cellular Immunology
Patent applications
1. SG Patent Application no: 10201602701S. A multimodal gluorescent probe for detecting vascular integrity and leakage
2. SG Patent Application no: 10202005589P. CD71 biomarker defines human neutrophil progenitors
3. Provisional Patent Application no: 10201800714R. Identification of human neutrophil developmental heterogeneity in healthy and diseased-state
4.International Application no: PCT/SG2019/050040. Neutrophi l subtype
5. SG Patent Application no: 10202012586X. A method of characterising an immunosuppressive neutrophil
6. SG Patent Application no: 10202012393V. A method for evaluating progression of an infectious disease and/or inflammatory disease
Research Grants
1.National Health and Medical Research Council (NHMRC): Defining neural regulation of the tumour immune ecosystem (2038669). 2025-2029. $1,256,356.80. ClA - Sapna Devi, ClB - L. G. Ng
2.National Natural Science Foundation of China (Research Fund for International Scientists): Deciphering the Role of Neutrophil-Derived Collagen in Tumor Progression (W2431020). 2025-2026. PI L. G. Ng
3.National Natural Science Fund of China (Major Research Project), Integrative neutrophil multiomics decoding biomarkers and therapeutic targets for autoimmune diseases (92374205). 2024-2027. PI L. G. Ng
4.National Key Research and Development Program of China (Key Special Project): The mechanism of innate effector-mediated pathogen capture and removal of migrating cells (2023YFC2306302). 2024-2026. PI L. G. Ng
5.National Key Research and Development Program of China (Key Special Project):阐明免疫新机制推动模型校正与方案优化 (2023YFC2506405). 2023-2026. Key members of the project
6.National Natural Science Foundation of China (General Program): Understanding Neutrophil Heterogeneity in Tumor. 2023-2026. PI L. G. Ng
7.Ministry of Science and Technology of China (Foreign Experts Program): Effect of neutrophils on wound healing in diabetic state and blood glucose homeostasis. 2022-2024. PI L. G. Ng
8. Shared Infrastructre Support Grant (SIS): SingaScope: A Singapore-wide Micrscoppy Network (NRF2017_SISFP10). 2019-2024. PI: Graham Wright, Co-I: L. G. Ng
9. Industry Alignment Fund (Pre-positioning): SInGapore ImmuNogrAm for Immuno-OncoLogy (SIGNAL) (H19/01/a0/024). 2019-2023. PI: Laurent Renia and David Tan, Imaging Theme Co-PI: L. G. Ng
10. Industry Alignment Fund (Pre-positioning): Cancer ImmunoTherapy Imaging (CITI) Programme: Precision Immune Cell Imaging for Precision Cancer Immunotherapy (H18/01/a0/018). 2018-2023.PI: Ann-Marie Chacko and Daniel Tan, Imaging Theme Co-I: L. G. Ng
11. Skin Innovation Grant: Modulation of Biomaterial-mediated wound healing response by biomimetic polymeric surface (SIG18027). 2018-2020. PI: Dang Thuy Tram, Co-I: L.G. Ng
12. NMRC Clinician Scientist Award: Three-dimensional imaging in ex vivo skin and non-invasive skin imaging: novel clinical applications in skin cancers and hypohidrotic sweat disorders (SRG/14019). 2018-2021. Clinical PI: Tey Hong Liang, Co-I: L. G. Ng
13. NHMRC Project Grants: A unique network of phagocytic cells at the interface between the liver and peritoneal cavity. 2016-2019. CIA: P. Bertolino, CIB: D. Bowen, CIC: B. Saunders and CID: L.G. Ng
14. NHMRC Project Grants: Dynamics and mechanisms of immune complex-mediated skin inflammation. 2016-2019. CIA: W. Weninger and CIB: L.G. Ng
15. NHG Small Innovative Grants: Genomic Profiling of Type III hypersensitivity in Cutaneous Vasculitis (SIG/15501). 2015-2017. Clinical PI: H.L. Tay, Non-Clinical PI: L.G. Ng
16. NMRC Coorperative Basic Research Grant: Mast cell-driven T cell responses during acute viral infection (NMRC/CBRG/0084/2015). 2015-2018. Principal Investigator: A.L. St John, Co-I: L.G. Ng and Lisa Ng
17. A-STAR-NHG-NTU Skin Research Grants: Pathophysiology of itch in atomic dermatitis and psoriasis (SRG/14019). 2014-2017. Clinical PI: H.L. Tay, Non-Clinical PI: L.G. Ng
18. 12th JCO Grants: Development of cross-platform imaging probes for the study of neutrophil function in vivo (1431AFG108). 2013-2014. Project Director: L.G. Ng, Lead Investigators: B Liu and K Li.
19. A*STAR-MINDEF Grants: The development of a broadly protective influenza vaccine and visualization of immunological changes mediated by an immuno-modulating agent as mechanistic basis for effective medical countermeasures with military applications (10/1/50/19/669). 2011-2014.Lead Investigator: Gary Lau and Co-Investigator: L.G. Ng
20. Cancer Institute NSW Research Innovation Grants: Intravital cell-cycle imaging as a novel approach to design combined targeting strategies of independent signaling pathways in melanoma. 2009.CIA: N. Haass and CIB: L.G. Ng
21. NHMRC Project Grants: Real-time visualisation of dendritic cell responses during cutaneous Leishmania infection. 2009-2011. CIA: W. Weninger and CIB: L.G. Ng
22. The Clive And Vera Ramaciotti Foundations Establishment Grants: Visualising the structural changes of the lung during inflammatory responses by multiphoton microscopy. 2009. CIA: L.G. Ng
23. ARC FABL Network Support Grants: Development and optimisation of OPO-based multiphoton fluorescence imaging. 2008. CIA: A.L. Smith and CIB: L.G. Ng
24. The University of Sydney Bridging Support Grants: Real-time visualisation of dendritic cell responses in the skin. 2008.CIA: W. Weninger and CIB: L.G. Ng