Research team leader

Ng Lai Guan

Professor, Senior Investigator

Professor at Westlake University

Research directions
1. Differentiation mechanism and migration characteristics of neutrophils and monocytes
2. Heterogeneity of neutrophils in tumors
3. Functional study of neutrophils in type 2 diabetes

News

May. 2025

the latest review by hLife from Lai Guan Ng team: Neutrophils and metabolic syndrome – key roles and development prospects

Clinical data show that the prevalence of metabolic syndrome (MetS) in our country is 33.9%, and the risk of cardiovascular and cerebrovascular diseases in MetS patients is 3 times higher than that of healthy people. MetS is mainly characterized by metabolic abnormalities such as insulin resistance, obesity, and hypertension, and its core pathogenesis is closely related to the interaction of chronic low-grade inflammation and immunometabolic imbalance. Recent studies have found that neutrophils,

May. 2025

Double Jie on the list! The 2025 Best Scientists in the Field of Immunology has just been released. Academician Dong Chen from our institute ranked 4th in China, and Professor Lai Guan Ng ranked 20th.

Recently, the world-renowned academic research platform Research.com released the ranking of the best scientists in the field of immunology in 2025, and Academician Dong Chen, founding president of the Shanghai Immune Therapy Institute, ranked 4th in China and 295th in the world; Professor Lai Guan Ng, a senior researcher at the Institute, is ranked 20th in China and 2095th in the world. The two scholars have made breakthroughs in the fields of T cell differentiation mechanism and m

Jan. 2025

Researcher Lai Guan Ng from Renji Hospital, in collaboration with the international team, published a review in Immunity: Revealing the adaptation mechanism of neutrophils and exploring new cancer treatment strategies

On January 14, 2025, Lai Guan Ng, a senior researcher at our institute, together with Daniela Cerezo-Wallis and Andres Hidalgo, professors at Yale University School of Medicine, and Melissa Ng, a researcher at the Singapore Science and Technology Research Authority (A*STAR), published a review titled "Adaptations of neutrophils in cancer" online in Immunity. This review provides an in-depth analysis of the adaptation mechanisms of neutrophils in the cancer environment and, based on these finding

Dec. 2024

Good news | Lai Guan Ng, a senior researcher at our institute, and the Duherty Institute of the University of Melbourne have won the NHMRC Innovation Grant Program in Australia

Recently, Professor Lai Guan Ng (Huang Laiyuan), a senior researcher at the Shanghai Immune Therapy Institute, and Dr. Sapna Devi from the Duherty Institute of the University of Melbourne in Australia jointly conducted a project "Defining Neural Regulation of the Tumour Immune" Ecosystem) has been awarded the latest round of innovation funding from Australia's National Health and Medical Research Council (NHMRC). The four-year grant program aims to support research teams from both