Studies have revealed for the first time that neutrophils in the tumor microenvironment have the function of adapting to environmental signals regardless of whether they are mature or not, and can converge to form a terminal state of pro-tumor phenotype through technologies such as Schenasek and Infinitivlov. In homeostasis, the ability of neutrophils to remodel in response to tissue signals is conducive to tissue homeostasis regulation. In pathological conditions such as tumors, this reprogramming ability of neutrophils will produce a large number of pro-angiogenic special 3 neutrophils to support tumor growth. The study shows that although neutrophils have a shorter lifespan, they also have the ability to modulate their actions according to different tissue signals to adapt to different tissue microenvironments, which also means that immunotherapy strategies targeting neutrophils have unlimited potential.

Paper link: https://www.science.org/doi/10.1126/science.adf6493